NMA: Nonprescription Medicines Academy

Patient Safety Alert

August 31st, 2009

Glucose test strips that use the reagent glucose dehydrogenase pyrroloquinolone quinine (GDH-PQQ) can cause falsely elevated blood glucose results in patients who receive therapeutic products that contain or are metabolized to maltose, xylose, galactose, or certain other nonglucose sugars.

The falsely elevated results may mask significant hypoglycemia or prompt excessive insulin administration, leading to serious injury or death. Products that contain nonglucose sugars include certain peritoneal dialysis solutions and immunoglobulins (e.g., abatacept, tositumomab). [Link]

Author: Cynthia Knapp Dlugosz, BPharm