Draft USPSTF Guidelines Questions Usefulness of Vitamin D, Calcium Supplements for Primary Prevention of Fractures or Cancer | Nonprescription Medicines Academy

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Draft USPSTF Guidelines Questions Usefulness of Vitamin D, Calcium Supplements for Primary Prevention of Fractures or Cancer

August 1st, 2012

In a draft recommendation statement addressing vitamin D and calcium supplementation to prevent cancer and osteoporotic fractures in adults, the U.S. Preventive Services Task Force (USPSTF) recommends against daily supplementation with ≤400 IU of vitamin D3 and 1,000 mg of calcium carbonate for the primary prevention of fractures in noninstitutionalized postmenopausal women. The USPSTF also concludes that evidence is lacking regarding:

  • Daily supplementation with >400 IU of vitamin D3 and 1,000 mg of calcium for the primary prevention of fractures in postmenopausal women.
  • Combined vitamin D and calcium supplementation for the primary prevention of fractures in premenopausal women or in men.
  • Vitamin D supplementation, with or without calcium, for the primary prevention of cancer in adults.

As a result, the balance of benefits and harms for these uses cannot be determined.

The draft recommendation statement is based on an evidence review that was published in December 20, 2011 (available at http://www.uspreventiveservicestaskforce.org/uspstf12/vitamind/vitdart.htm). That review included data from 19 randomized, controlled trials (3 for cancer and 16 for fracture outcomes) and 28 observational studies (for cancer outcomes).

The full text of the draft recommendation statement can be accessed at http://www.uspreventiveservicestaskforce.org/uspstf12/vitamind/draftrecv.... Comments were being accepted through July 10, 2012.