NMA: Nonprescription Medicines Academy

Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation

December 14th, 2012

Data from a nationally representative sample of 9,947 adults indicate that glucosamine, chondroitin, and fish oil supplements are associated with reduced inflammation, as measured by serum high-sensitivity C-reactive protein (hs-CRP) concentration. The magnitude of reduction in hs-CRP ranged from 16% to 22%.

The analyses were based on data collected as part of the 1999–2000, 2001–2002, and 2003–2004 cycles of the National Health and Nutrition Examination Survey (NHANES). Using survey-weighted multivariate linear regression, significant reductions in hs-CRP concentrations were associated with regular use of glucosamine (17% reduction; 95% CI, 7–26), chondroitin (22% reduction; 95% CI, 8–33), and fish oil (16% reduction; 95% CI, 0.3–29). No associations were observed between hs-CRP concentration and regular use of supplements containing methylsulfonylmethane, garlic, ginkgo biloba, saw palmetto, or pycnogenol.

Am J Epidemiol. 2012;176:1002-13.