LiverTox is a new source of evidence-based information about liver injury associated with prescription and nonprescription drugs, herbals, and dietary supplements.
Regular use of aspirin after diagnosis appears to offer a significant survival benefit for the 15% to 20% of patients with colorectal cancer who have mutations in PIK3CA (the gene encoding phosphatidylinositol-4,5-bisphosphonate 3-kinase, catalytic subunit alpha polypeptide).
The results of a pharmacovigilance study support an association between nonsteroidal anti-inflammatory drug use and poorer antidepressant outcomes in major depressive disorder, but some of the observed effect may be attributable to confounding.
The results of a pharmacovigilance study support an association between nonsteroidal anti-inflammatory drug use and poorer antidepressant outcomes in major depressive disorder, but some of the observed effect may be attributable to confounding.
In a study designed to examine the effect of low-dose aspirin therapy on cognitive function in an elderly population, aspirin therapy was found to have a neuroprotective effect in women at high risk for cardiovascular disease.
In a systematic review and meta-analysis of 20 randomized, controlled trials, prophylactic use of probiotics (Bifidobacterium, Lactobacillus, Saccharomyces, or Streptococcus species) by adults and children receiving antibiotics reduced the incidence of Clostridium difficile–associated diarrhea by 66%.
Data from a nationally representative sample of 9,947 adults indicate that glucosamine, chondroitin, and fish oil supplements are associated with a 16% to 22% reduction in inflammation, as measured by serum high-sensitivity C-reactive protein (hs-CRP) concentration.